vancomycin powder for injection  (Mylan Lab)

Journal: Frontiers in Medicine

Article Title: Development of an innovative in vivo model of PJI treated with DAIR

doi: 10.3389/fmed.2022.984814

Figure Lengend Snippet: Experimental design. The animals were assigned to three groups of five animals each. Group A animals were used to confirm the validity of the implants designs and to assay the pharmacokinetics of vancomycin; Group B animals were used to confirm the adequacy of the bacterial inoculum; Group C animals were infected and treated with a surgical debridement followed by the intra-articular injection of Tris-HCl buffer and a 1 week course of IV vancomycin.

Article Snippet: Vancomycin powder for injection (Mylan bvba, Hoeilaart, Belgium) was reconstituted with 0.9% saline (Baxter SA, Lessines, Belgium) at a 50 mg/ml concentration.

Techniques: Drug discovery, Infection, Injection

Journal: Frontiers in Medicine

Article Title: Development of an innovative in vivo model of PJI treated with DAIR

doi: 10.3389/fmed.2022.984814

Figure Lengend Snippet: Serum concentration (mg/L) of vancomycin evolution following the first (A) and fifth (B) injections in group A rabbits. (C) Box plots of the AUC 0–12 h after the first (left) and fifth (right) injections. AUC 0–12 h were computed using the trapezoidal method. AUC 0–12 h were compared with the Wilcoxon test. N = 5. (D) Box plots of the serum concentrations of vancomycin 6 h after injection in groups A and C. Concentrations were compared with the Welch corrected t -test following normality evaluation using the Kolmogorov Smirnov test. N = 10 (group A), 15 (groups C).

Article Snippet: Vancomycin powder for injection (Mylan bvba, Hoeilaart, Belgium) was reconstituted with 0.9% saline (Baxter SA, Lessines, Belgium) at a 50 mg/ml concentration.

Techniques: Concentration Assay, Injection

Journal: Scientific Reports

Article Title: Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units

doi: 10.1038/s41598-021-82312-2

Figure Lengend Snippet: Intermediate models showing the influence of the different covariates on the vancomycin pharmacokinetic parameters.

Article Snippet: The dosage regimens of vancomycin (powder injection from Eli Lilly or Xinchang) were designed by experienced clinicians based on the patient's condition and renal function, including 0.5 g qd, 0.5 g q12h, 0.5 g q8h, 0.5 g q6h, 1 g qd, and 1 g q12h.

Techniques:

Journal: Scientific Reports

Article Title: Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units

doi: 10.1038/s41598-021-82312-2

Figure Lengend Snippet: Goodness-of-fit plots of the final model for vancomycin. ( A ) Individual predictions of vancomycin versus observed concentrations. ( B ) Individual predictions of vancomycin versus predicted weighted residuals. ( C ) Individual predictions of vancomycin versus predicted residuals. ( D ) Gaussian distribution of weighted residuals.

Article Snippet: The dosage regimens of vancomycin (powder injection from Eli Lilly or Xinchang) were designed by experienced clinicians based on the patient's condition and renal function, including 0.5 g qd, 0.5 g q12h, 0.5 g q8h, 0.5 g q6h, 1 g qd, and 1 g q12h.

Techniques:

Journal: Scientific Reports

Article Title: Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units

doi: 10.1038/s41598-021-82312-2

Figure Lengend Snippet: Goodness-of-fit plots of external validation. ( A ) Individual predictions of vancomycin versus observed concentrations. ( B ) Individual predictions of vancomycin versus predicted weighted residuals.

Article Snippet: The dosage regimens of vancomycin (powder injection from Eli Lilly or Xinchang) were designed by experienced clinicians based on the patient's condition and renal function, including 0.5 g qd, 0.5 g q12h, 0.5 g q8h, 0.5 g q6h, 1 g qd, and 1 g q12h.

Techniques: Biomarker Discovery

Journal: Scientific Reports

Article Title: Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units

doi: 10.1038/s41598-021-82312-2

Figure Lengend Snippet: Vancomycin PPK model studies in adult patients by the nonlinear mixed-effects modeling method.

Article Snippet: The dosage regimens of vancomycin (powder injection from Eli Lilly or Xinchang) were designed by experienced clinicians based on the patient's condition and renal function, including 0.5 g qd, 0.5 g q12h, 0.5 g q8h, 0.5 g q6h, 1 g qd, and 1 g q12h.

Techniques: